ABSTRACT:

The current clinical plasma proteome consists of 109 proteins measured by FDA-cleared or approved assays and 96 proteins measured using widely-available laboratory developed tests, in total about 1% of the baseline human proteome. However the rate at which new protein analytes achieve FDA approval has remained essentially constant over the past 15 years at 1.5 proteins per year, insufficient to meet clear medical needs. The striking shortfall in new protein diagnostics emerging from proteomics research reflects a lack of critical biomarker verification capacity. In order to bridge the gap between biomarker discovery and clinical use, a new approach to verification is proposed: multiplexed panels of specific candidate assays based on hybrid immuno-mass spectrometric (SISCAPA) detection. By combining high sensitivity, high throughput, and precision with use of small plasma samples, a platform for systematic verification of hundreds of candidates in thousands of samples can be implemented. Such systematic studies will finally allow us to test the “strong biomarker hypothesis”: that molecular biomarkers exist for all major disease states. An extension of this approach, the hPDQ project providing a library of specific tests for all 21,300 human proteins, could provide the larger biomedical research community with direct quantitative access to the entire human proteome.

SPEAKER BIOGRAPHY:

Dr. Anderson obtained his B.A. in Physics with honors from Yale and a Ph.D. in Molecular Biology from Cambridge University (England) where he worked with M. F. Perutz as a Churchill Fellow at the MRC Laboratory of Molecular Biology. Subsequently he founded (with Dr. Norman Anderson) the Molecular Anatomy Program at the Argonne National Laboratory (Chicago) where his work in the development of 2-D electrophoresis and molecular database technology earned him, among other distinctions, the 1983 Pittsburgh Analytical Chemistry Award. Prior to founding PPI, Dr. Anderson was Chief Scientific Officer at Large Scale Biology Corporation, whose proteomics division he founded in 1985, and co-led a successful IPO based largely on the proteomics technology platform (working with J.P. Morgan, Chase H&Q and Wm Blair).


More recently Dr. Anderson has developed novel technologies for quantitation of protein biomarkers using mass spectrometry, receiving the 2009 HUPO Distinguished Achievement Award in Proteomic Science. Dr. Anderson has published more than 150 scientific papers, one book and 32 patents. Dr. Anderson currently serves as a Principal of Anderson Forschung Group LLC, the Board of Directors of Luna Innovations (a developer of novel materials and sensors) and on numerous scientific advisory boards.


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If you would like to become a sponsor and have not done so, please contact Ahmed Elbaggari or Maryann Shen. BAMS corporate sponsors for 2010 will have a place to put up a technical poster and a table to distribute literature or demonstrate products during the Annual BAMS Vendor Night.
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We look forward to seeing you at the next meeting!
 
Respectfully, we remain your servants,

Your BAMS Executive Team.

Meeting details

Date:	Tuesday	February 2nd, 2010
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Presentation
Dinner:	featuring:	Dinner selections are: A) Flank Steak- Anise Marinade  B) Grilled Salmon- Champagne Buerre Blanc, Herb Roasted Veggies and Rice Pilaf. C) Mediterranian Farfalle Pasta with Sun Dried Tomatoes, Olives, Basil, Mushrooms(Vegetraian)
Cost:	$40	BAMS members*
	$50	Non-members
	$70	BAMS membership plus dinner cost
	$20	Students only
	$300	2009 Corporate Sponsors
		Dinner reservations required by 6:00 PM, Thursday the 28th of January, 2010

*Note:  BAMS memberships are for the calendar year and should be renewed with the first event you attend in 2010.  Dues ($30.00) may be paid while registering for dinner.  If you are unsure of your Membership status, please email Ahmed Elbaggari.

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