Thursday, December 7, 2000
6:00 pm to 10:00 pm
Hong Kong East Ocean Seafood Restaurant
Emeryville, CA
(Dinner reservations required by noon on Friday 12/1/00)
Proteomics in a Boutique Laboratory
Catherine Fenselau
University of Maryland
Abstract
In a time when proteomics is being rapidly developed following the
highly automated, high throughput industrial model, there is still room
for the individual investigator laboratory. We'll talk about some of the
reasons for this. A new technique for comparative proteomics will be presented,
in which two O-18 labels are incorporated into the peptide products of
enzymatic cleavage. This proteolytic labeling globally introduces a four
dalton mass difference into peptides derived from analogous proteins in
two complexes or two cell populations. Fourier transform mass spectrometry
is ideal for isotope ratio analysis of the resulting isotope pairs. This
approach has been evaluated in a comparison of adenovirus serotypes 2 and
5. Applications will also be discussed of proteomics and bioinformatics
technologies to the mammalian synthesome complex and to the rapid identification
of microorganisms.
Background
Catherine Fenselau grew up in Nebraska, received her A.B. degree from
Bryn Mawr College and her Ph.D. from Stanford University in the laboratory
of Carl Djerassi. After post-doctoral work with Melvin Calvin and A.L.Burlingame
at the University of California and the NASA Space Science Laboratory at
Berkeley, she joined the faculty of Johns Hopkins University's Medical
School. She was promoted to Professor there, and subsequently moved to
become Chair of the Chemistry and Biochemistry Departments at UMBC and
then at UMCP. She is presently Professor of Chemistry and Biochemistry
and a member of the Center for Molecular Structure and Cellular Organization
at UMCP. She has held visiting professorships at the University of Warwick
(UK) and Kansai Medical School (Japan). She was President of the American
Society for Mass Spectrometry, and founding editor of Biomedical Mass Spectrometry
(now J. Mass Spectrometry). Presently she is an associate editor for Analytical
Chemistry and chair-elect of the ACS Analytical Chemistry Division. She
has published 280 papers and book chapters in a career focussed primarily
on developing applications of mass spectrometry in pharmacology.
Meeting details
| Date: | Thursday | December 7, 2000 |
| Time: | 6:00 pm | Social hour, registration (no-host cocktails) |
| 7:00 pm | Dinner ($30/members; $40/non-member) | |
| 8:15 pm | Presentation (free, no reservations required) | |
| Dinner: | Choice of: | assorted Chinese (no pre-selection) |
| includes | various side dishes, desert, coffee, etc. | |
| Cost: | $30.00 | BAMS members. Reservations required by noon Friday 12/1/00 |
| $40.00 | Non-members. Reservations required by noon Friday 12/1/00 | |
| $15.00 | Students only. Reservations required by noon Friday 12/1/00 |
Maps
& directions
Hong Kong East Ocean Seafood Restaurant
3199 Powell St.
Emeryville, CA
510-655-3388
Our tentative schedule for speakers & meetings is as follows:
| Thursday, January 25, 2001 | Alan Marshall |
| Wednesday, March 14, 2001 | John Hayes |
Want to be a judge? The Intel International Science & Engineering Fair 2001 needs you! See the call for judges and/or their web site.
Other meeting notices received by BAMS:
2nd Workshop on Harsh-Environment Mass Spectrometry, 3/18/2001 (http://www.marine.usf.edu/mass_spec/HEMSconf.htm)
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