Abstract
The talk will focus mainly on the structural determination of N-linked glycans by modern mass spectrometric methods. Existing methods, based on mass spectrometry, liquid chromatography and exoglycosidase digestion will be summarised and their current drawbacks emphasised. The use of MALDI mass spectrometry for obtaining qualitative and quantitative data will be discussed, with particular emphasis on results obtained with electrospray ionization with Q-Tof and ion trap instruments. Results obtained with the new MALDI-Q-Tof instruments will then be presented for both N-linked glycans and glycolipids and some preliminary results with vacuum and atmospheric MALDI interfaced to ion traps will be described.

Background
Degrees:
    BSc, University of Hull, UK, 1962.
    MSc, University of Hull, UK, 1964.
    PhD, University of Glasgow, Scotland, 1968.
    DSc, University of Glasgow, Scotland, 1988.

Appointments:
    1968 - 1969, MRC Research Fellow, Department of Chemistry, University of Glasgow, GC/MS of steroids.
    1969 - 1972, Visiting Assistant Professor of Biochemistry, Institute for Lipid Research, Baylor College of Medicine, Houston, Texas, USA. GC/MS studies of carbohydrates, steroids and drug metabolites.
    1972 - 1982, Research Officer, Department of Pharmacology, University of Oxford. Mass spectrometry of cannabis and its metabolites and of lipids.
    1982 - 1990, Wellcome Senior Lecturer, Department of Pharmacology, University of Oxford. Work as above.
    1990 - 2000, Senior Research Fellow, Glycobiology Institute, Department of Biochemistry, University of Oxford. MALDI and electrospray mass spectrometry of carbohydrates.
    2000 - present, Reader in Glycobiology, Glycobiology Institute, Department of Biochemistry, University of Oxford. Work as above.

Meeting details

Date:	Wednesday	October 24, 2002
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Lecture
Dinner:	Choice of:	Chicken
		Pasta Primavera
	includes	(various side dishes & dessert)
Cost:	$25.00	BAMS members.  Reservations required by noon on Monday October 21, 2002
	$35.00	Non-members.  Reservations required by noon on Monday October 21, 2002
	$15.00	Students only.  Reservations required by noon on Monday October 21, 2002

Note: 2002 dues need to be paid to obtain member price.  Dues ($20) may be paid while registering for dinner.

Maps & directions
Hs Lordship's Restaurant
199 Seawall Drive
Berkeley, CA  94710
510-843-2733
Yahoo map

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The San Francisco Bay Area Mass Spectrometry discussion group was formed in 1980 to provide a regular gathering for people interested in mass spectrometry and allied topics. BAMS currently has a membership of about 280 individual and 20 corporate members, and meets 8-10 times per year for a midweek dinner and lecture.  Meetings attract between 30 and 90 people, and are held at a restaurant or hotel in the bay area convenient for our speaker.  We usually convene at 6:00 pm for cocktails, dinner at 7:00 pm, and lecture at 8:15 pm.

If you have suggestions for a meeting topic, or know of a prominent mass spectroscopist who will be visiting the bay area, please contact our program chair.

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BAMS has been fortunate to have had many excellent speakers in our short history.
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Last update: 10/14/2002