Abstract
Mass spectrometry is one of the most important analytical tools to characterize and identify minute amounts of molecules in complex mixtures and is becoming a very sensitive detector in separation sciences. We are developing a unique form of time-of-flight mass spectrometry (TOFMS), called Hadamard transform TOFMS (HT-TOFMS), which offers faster acquisition rates and higher signal-to-noise ratios than traditional TOFMS methods. In this method a continuous ion beam emerging from an ion source is accelerated and then modulated by a pseudo-random sequence of "on" and "off" pulses. The pseudo-random sequence is derived from the Hadamard matrix. The data is acquired synchronously with the modulation of the ion beam, and the modulation sequence is deconvoluted from the data using a Hadamard transformation to extract the time-of-flight distribution of the ions. This multiplexing scheme increases the ion usage to approximately 50% (normal multi-channel plate detector) or approximately 100% (structured multi-channel plate detector) and improves the signal-to-noise level considerably over that of conventional TOFMS. The fundamentals, development, and application of this technique will be discussed.

Support from the Air Force Office of Scientific Research is gratefully acknowledged.

Background
Dr. Oliver Trapp studied Chemistry at the University of Tuebingen, Germany, where he received  the Diploma in Inorganic, Organic and Physical Chemistry in 1998 and also did his Diploma and PhD thesis on the stereochemical stability of chirotopic nitrogen compounds. He developed the ChromWin simulation program that allows the fast determination of  interconversion barriers of enantiomers, epimers and diastereomers by dynamic chromatographic methods. In April 2002, he joined the Department of Chemistry at Stanford University as post-doc with R.N. Zare. He is the author over 26 scientific publications, 41 poster presentations and numerous oral presentations

Meeting details

Date:	Thursday	January 29, 2004
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Lecture
Dinner:	Buffet featuring:	Salmon Stuffed with a Shrimp Mousse
		Chicken Breasts with a Wild Mushroom Sauce
		Winter Vegetable Sauté
	includes	various side dishes & dessert
Cost:	$25.00	BAMS members.  Reservations required by noon on Friday January 23,2004
	$35.00	Non-members.  Reservations required by noon on Friday January 23,2004
	$15.00	Students only.  Reservations required by noon on Friday January 23,2004

Note: 2004 dues need to be paid to obtain member price.  Dues ($20) may be paid while registering for dinner.

Maps & directions
Roche BioSciences
3401 Hillview Ave
Palo Alto, California 94303
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The San Francisco Bay Area Mass Spectrometry discussion group was formed in 1980 to provide a regular gathering for people interested in mass spectrometry and allied topics. BAMS currently has a membership of about 280 individual and 20 corporate members, and meets 8-10 times per year for a midweek dinner and lecture.  Meetings attract between 30 and 90 people, and are held at a restaurant or hotel in the bay area convenient for our speaker.  We usually convene at 6:00 pm for cocktails, dinner at 7:00 pm, and lecture at 8:15 pm.

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Last update: 1/15/2004