BAMS

The San Francisco Bay Area Mass Spectrometry (BAMS) discussion group

Tuesday September 13, 2005
6:00 pm to 9:00 pm

Crowne Plaza Hotel
Foster City, CA

Dinner reservations required by noon on Friday September 9, 2005

Metabonomics: Principles and Practice

John P. Shockcor, Ph.D.
Business Development Manager, Metabolic Profiling
Waters Corp.

Abstract
    From the post genomics and proteomics era, metabonomics has emerged as a vital new area of research. Metabolic profiles of biological fluids contain a vast array of endogenous low-molecular weight metabolites, the composition of which depends upon the sample type (plasma urine, bile etc) and factors such as the species, age, sex, diet of the organism from which the sample derives and indeed even the time of day at which the sample was taken. Disease, drugs (and other biologically active molecules) perturb concentrations and fluxes in intermediary metabolic pathways. The response to this perturbation involves adjustment of intracellular and extracellular environments in order to maintain homeostasis. Both the perturbations and the adjustments are expressed as changes in the normal composition of the biofluids or tissues that can be characteristic of the nature or site of the disease process, toxic insult, pharmacological response or genetic modification.

    Metabonomics uses data from information rich analytical techniques, in particular, MS and/or NMR, which provide spectral patterns that can be evaluated using statistical methods, such as principal component analysis (PCA), to highlight both subtle and gross systematic differences between samples. Evaluation of these observed biochemical changes over time can provide critical information on the mechanism of the perturbation. Traditional metabolic profiling methods can also be used to evaluate the endogenous changes and any xenobiotic biotransformations which might occur in test subjects.

    In this talk we will present data to illustrate these concepts and demonstrate the application of both metabonomics and metabolic profiling studies to drug discovery and development.

Meeting details

Date:	Tuesday	September 13, 2005
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Lecture
Dinner:	featuring:	Rock Salt & Pepper Crusted Prime Rib of Beef Au Jus and Whipped Horse Radish with Garlic Mashed Potatoes
		Roasted Chicken with a Ginger Soy Sauce
		Mediterranean Bowtie Pasta, Sun-Dried Tomatoes, Mushrooms, Kalamata Olives, Feta Cheese, Basil and Spinish with Sliced Garlic with Extra Virgin Olive OIl
	includes:	Seasonal Vegetables, Rolls/Butter, Cheesecake with Strawberry Puree, Coffee/Tea
Cost:	$30	BAMS members.
	$40	Non-members.
	$60	BAMS membership plus dinner cost
	$15	Students only.
	$300	2005 Corporate Sponsors
		Dinner reservations required by noon on Friday September 9, 2005

*Note: 2005 dues need to be paid to obtain member price. Dues ($30.00) may be paid while registering for dinner. If you are unsure of your 2005 Membership status, please email David Kage.

Maps & directions
Crowne Plaza
1221 Chess Dr.
Foster City, CA 94404
(650) 570-5700
maps.google.com directions

Did you see or hear about the BAMS talk by Professor Murayama entitled "What is Mass?" What is it we are measuring after all? Check it out! Go to ctp.berkeley.edu and click on "Popular Talks & Articles" for a QuickTime file.

As a service to our members, we post Employment postings.

As a trial service to our members, we are now posting Situations Wanted. (Note: BAMS isn't a career center and will only post brief positions wanted for BAMS members only).

The San Francisco Bay Area Mass Spectrometry discussion group was formed in 1980 to provide a regular gathering for people interested in mass spectrometry and allied topics. BAMS currently has a membership of about 280 individual and 20 corporate members, and meets 8-10 times per year for a midweek dinner and lecture. Meetings attract between 30 and 90 people, and are held at a restaurant or hotel in the bay area convenient for our speaker. We usually convene at 6:00 pm for cocktails, dinner at 7:00 pm, and lecture at 8:15 pm.

If you have suggestions for a meeting topic, or know of a prominent mass spectrometrist who will be visiting the bay area, please contact our program chair.

To become a member, please fill out and mail in a membership form.
BAMS has been fortunate to have had many excellent speakers in our short history.
If you have suggestions for a meeting topic please contact our program chair.
If you have questions or comments about BAMS, please contact one of the BAMS officers.
Please thank our corporate sponsors who help keep BAMS membership and dinner costs low.
Here are some internet links that may be of interest to BAMS members.

If you have comments or suggestions for this web site, please email me at hugh-gregg@llnl.gov

Last update: 8/29/2005