BAMS

The San Francisco Bay Area Mass Spectrometry (BAMS) discussion group

Wedneaday March 22, 2006
6:00 pm to 9:30 pm

Crowne Plaza Hotel
Foster City, CA

Dinner reservations required by noon on Friday March 17, 2006

Top Down, Middle Down, and Sideways: Emergent Approaches for Interrogation of Intact Proteins and Post-Translational Modifications

Professor Neil L. Kelleher
University of Illinois

Abstract

New approaches to protein and proteome analysis will be described using "Large Molecule" Mass Spectrometry. They combines new informatics with a Quadrupole/ and QIT/Fourier-Transform hybrid mass spectrometers to enable efficient characterization of biological events that change the mass of protein molecules from that predicted by an annotated DNA sequence. "Top Down" and "Middle Down" Mass Spectrometry hold promise for streamlined protein characterization (i.e., PTMs), improved diagnostics and a deeper understanding of the signaling and regulatory "codes" eukaryotic cells use that are written in the language of post-translational modification. Protein examples from yeast and human cells will be described, including characterization of histone modifications using a new database strategy termed "shotgun annotation".

Background

Professor Kelleher received a B.S. and B.A. from Pacific Lutheran University in 1992, a Fulbright Fellowship the following year, and a Ph.D. with Tadhg Begley and Fred McLafferty (Cornell University) in 1997. After an NIH Postdoctoral Fellowship with Chris Walsh (Harvard Medical School), Kelleher joined the faculty at the University of Illinois in 1999. He has received several awards including a Packard Fellowship, the NSF CAREER Award, the Lilly Analytical Chemistry Award, and support from the Burroughs Wellcome, the Searle, the Dreyfus Foundations and Presidential Early Career Award in Science and Engineering. Kelleher has interest in Mass Spectrometry-based enzymology and "Top Down" proteomics using intact proteins for efficient detection of their post-translational modifications.

Meeting details

Date:	Wednesday	March 22, 2006
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Lecture
Dinner:	featuring:	Prime Rib of Beef Au Jus with Garlic Mashed Potatoes
		Roasted Chicken Breast Ginger Soy
		Mediterranean Bowtie Pasta Sun-Dried Tomatoes, Mushrooms, Kalamata Olives, Feta Cheese, Basil and Spinach with Sliced Garlic with Extra Virgin Olive Oil
	includes:	Side dishes, dessert, Coffee/Tea
Cost:	$30	BAMS members*
	$40	Non-members
	$60	BAMS membership plus dinner cost
	$15	Students only
	$300	2006 Corporate Sponsors
		Dinner reservations required by noon on Friday March 17, 2006

*Note: BAMS memberships are for the calendar year and should be renewed with the first event you attend in 2006. Dues ($30.00) may be paid while registering for dinner. If you are unsure of your Membership status, please email Carol Soppe.

Maps & directions

Crowne Plaza
1221 Chess Dr.
Foster City, CA 94404
(650) 570-5700
maps.google.com directions

Did you see or hear about the BAMS talk by Professor Murayama entitled "What is Mass?" What is it we are measuring after all? Check it out! Go to ctp.berkeley.edu and click on "Popular Talks & Articles" for a QuickTime file.

As a service to our members, we post Employment postings.

As a trial service to our members, we are now posting Situations Wanted. (Note: BAMS isn't a career center and will only post brief positions wanted for BAMS members only).

The San Francisco Bay Area Mass Spectrometry discussion group was formed in 1980 to provide a regular gathering for people interested in mass spectrometry and allied topics. BAMS currently has a membership of about 280 individual and 20 corporate members, and meets 8-10 times per year for a midweek dinner and lecture. Meetings attract between 30 and 90 people, and are held at a restaurant or hotel in the bay area convenient for our speaker. We usually convene at 6:00 pm for cocktails, dinner at 7:00 pm, and lecture at 8:15 pm.

If you have suggestions for a meeting topic, or know of a prominent mass spectrometrist who will be visiting the bay area, please contact our program chair.

To become a member, please fill out and mail in a membership form.
BAMS has been fortunate to have had many excellent speakers in our short history.
If you have suggestions for a meeting topic please contact our program chair.
If you have questions or comments about BAMS, please contact one of the BAMS officers.
Please thank our corporate sponsors who help keep BAMS membership and dinner costs low.
Here are some internet links that may be of interest to BAMS members.

If you have comments or suggestions for this web site, please email me at hugh-gregg@llnl.gov

Last update: 3/10/2006