The San Francisco Bay Area Mass Spectrometry (BAMS)
discussion
group
Thursday March 27, 2008
6:00 pm to 9:30 pm
Basque Cultural Center
South San Francisco, CA
Dinner reservations required by
noon on Monday March 24, 2008
Developing gas-phase Ion Mobility Spectrometry
(IMS)-MS and Overtone Mobility Spectrometry (OMS)-MS techniques for
analysis of
biomolecules
Professor David Clemmer
Department of Chemistry
University of Indiana
Abstract
Upon being electrosprayed into the gas phase macromolecules may
establish a
range of conformations. The stable ones may be separated in a
drift tube
based on differences in the ions mobility through a gas under the
influence of
a field. This talk will describe the development of early IMS-MS
techniques for understanding protein ion conformation and the more
recent
development of multidimensional IMS-IMS-MS and IMS-IMS-IMS-MS methods
for
probing structural transitions. One of the results of the
multidimensional approach is a general method for rapid analysis of
complex
mixtures. As we have worked on these methods we found that when
many
drift tubes are serially combined (>20 regions for one instrument)
it is
possible to operated the drift fields in a way that creates an ion
filter (that
discriminates between ions based on differences in the ions
mobilities).
Very early work on this instrument indicates that it can be operated
using a
continuous beam of ions (with no initial drift pulse); additionally,
there are
advantages of operating the drift field frequency at specific
overtones.
Examples of separations of different oligosaccharide isomers as well as
mixtures of peptides will be given. The resolving power of this
method
scales differently than traditional IMS and may have significant
advantages in
developing much higher resolution instrumentation.
Speaker
Background
Professor Clemmer received a Ph.D. in Chemistry from the University of
Utah
and did postdoctoral work at the Himeji Institute of Technology (Japan)
and
Northwestern University before coming to IU in 1995. His research
involves the development of methods for studying the structures of
complex
low-symmetry systems in the gas phase. These methods are being
applied to
several types of problems including elucidation of fundamental issues
associated with how a protein folds, as well as studies of complex
mixtures of
proteins – the emerging field of proteomics. Professor Clemmer
has
published more than 110 papers and his work has been recognized with
several
awards, including the Fresenius Chemistry Award, the Biemnann Medal
from ASMS,
and the Pittcon Achievement Award in 2002 . He has been a member
of the
US Defense Science Study group.
Professor Clemmer's official title is: Robert & Marjorie Mann
Chair.
Meeting
details
| Date: |
Thursday |
March 27, 2008 |
| Time: |
6:00 pm |
Social hour, registration (no-host cocktails) |
|
7:00 pm |
Dinner |
|
8:00 pm |
Presentation |
Dinner:
|
featuring:
|
Veal Roast |
|
|
Breast of Chicken |
|
|
Salmon |
|
|
Vegetarian Pasta |
| Cost: |
$30
|
BAMS members* |
|
$40
|
Non-members |
|
$60
|
BAMS membership plus dinner cost |
|
$20
|
Students only |
|
$300
|
2008 Corporate Sponsors |
|
|
Dinner reservations
required
by noon on Monday March 24, 2008
|
*Note: BAMS memberships are for the calendar
year and should
be renewed with the first event you attend in 2008. Dues ($30.00)
may be paid while registering for dinner. If you
are
unsure of your Membership status, please email
Tim Hawkins.
Maps & directions
Basque Cultural Center
599 Railroad Avenue
South San Francisco, CA 94080
Google
Map of Basque Cultural Center
Restaurant Phone: (650) 583-8091
If you would like to
subscribe/unsubscribe or make changes to your email address in our
distribution
list, please email
Yingying Huang.
Did you see or hear about the BAMS talk by Professor Murayama
entitled
"What is Mass?" What is it we are measuring after
all?
Check it out! Go to ctp.berkeley.edu
and click on "Popular Talks & Articles" for a QuickTime file.
As a service to our members, we post Employment
postings.
The San Francisco Bay Area Mass Spectrometry discussion group was
formed
in 1980 to provide a regular gathering for people interested in mass
spectrometry
and allied topics. BAMS currently has a membership of about 280
individual
and 20 corporate members, and meets 8-10 times per year for a midweek
dinner
and lecture. Meetings attract between 30 and 90 people, and are
held
at a restaurant or hotel in the bay area convenient for our
speaker.
We usually convene at 6:00 pm for cocktails, dinner at 7:00 pm, and
lecture
at 8:15 pm.
If you have suggestions for a meeting topic, or know of a prominent
mass spectrometrist who will be visiting the bay area, please contact
our
program
chair.
To become a member, please fill out and mail in a membership
form.
BAMS has been fortunate to have had many excellent
speakers in our history.
If you have suggestions for a meeting topic please contact our program
chair.
If you have questions or comments about BAMS, please contact one of
the BAMS officers.
Please thank our corporate sponsors who
help keep BAMS membership and dinner costs low.
Here are some internet links that may be of
interest to BAMS members.
If you have comments or suggestions for this web site, please email
me at hugh-gregg@llnl.gov
Last update: 3/6/2008