Abstract
We have been involved in studies of the hepatotoxicity of acetaminophen in mice in vivo. Metabolism of acetaminophen by P450 generates a reactive chemical intermediate, an iminoquinone, that reacts with liver glutathione and is excreted normally as the GSH conjugate.  However, administration of doses that deplete liver glutathione levels gives rise to irreversible liver damage that is often fatal in humans and animals.  This damaged correlates with drug/protein binding levels.  We have been involved in the identification of these protein targets in order to gain insight into the mechanistic nature of centrilobular liver necrosis.
 

Background
BS Chemistry University of Rhode Island 1959, Ph.D. Chemistry MIT 1962, Guggenheim Fellow, Karolinska Institute 1970.  Director Mass Spectrometry Facility UC Berkeley  until 1978 and since then at UCSF.  Currently Professor of Chemisty and Pharmceutical Chemistry, UCSF and Professor of Biochemistry and Molecular Biology, University College, London.
 

Meeting details

Date:	Tuesday	February 23, 1999
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner ($25 includes wine)
	8:15 pm	Lecture (free, no reservations required)
Dinner:	Choice of:	Chicken Picatta w/Mushroom, Shallot, White Wine & Capers
		Sliced Roast Beef topped with Bordelaise Sauce
		Pasta Primavera
	includes	salad, desert, wine, coffee
Cost:	$25.00	Reservations required by Thursday February 18, 1999
	$10.00	Students only

Park Plaza Hotel
1177 Airport Boulevard
Burlingame CA.
650-342-9200
(for directions)
 
Congratulations to our new BAMS officers!  Scot Weinberger was elected Program Chair, Carolyn Koester and Mari Prieto were elected co-Treasurers, and Emily Sible was elected as Secretary for another year.  Per BAMS tradition (it may even be in our bylaws), David Sparkman, past Program Chair, becomes BAMS Chairman, and Hugh Gregg is shuttled off as Immediate Past Chair. BAMS wishes to thank George Stafford, the outgoing Immediate Past Chair, for his service to our organization.

Please note that BAMS has switched from a school year (September 1 to August 31) to a calendar year (January 1 to December 31).  So its now time to pay your dues for 1999!  Please see our membership form.

The San Francisco Bay Area Mass Spectrometry discussion group was formed in 1980 to provide a regular gathering for people interested in mass spectrometry and allied topics. BAMS currently has a membership of about 280 individual and 20 corporate members, and meets 8-10 times per year for a midweek dinner and lecture.  Meetings attract between 30 and 90 people, and are held at a restaurant or hotel in the bay area convenient for our speaker.  We usually convene at 6:00pm for cocktails, dinner at 7:00pm, and lecture at 8:15pm.
 
If you have suggestions for a meeting topic, or know of a prominent mass spectroscopist who will be visiting the bay area, please contact our program chair.
 

*NEW* Employment postings.

To become a member, please fill out and mail in a membership form.
BAMS has been fortunate to have had many excellent speakers in our short history.
If you have suggestions for a meeting topic please contact our program chair.
If you have questions or comments about BAMS, please contact one of the BAMS officers.
Please thank our corporate sponsors who help keep BAMS membership and dinner costs low.
Here are some internet links that may be of interest to BAMS members.
 

If you have comments or suggestions for this web site, please email me at hugh-gregg@llnl.gov

Last update: 2/16/99.