Abstract
Tandem mass spectrometry (MS/MS) is a potent method for obtaining structural information of analytes. The ion activation step in the MS/MS experiment almost always involves a collision between the parent ion and a target gas, so-called collision induced dissociation (CID). Ion traps can be particularly efficiently at CID, albeit with some limitations. However, because of the ion manipulation capabilities of ion traps they also offer opportunities, often unique, for other activation methods using photons or/and electrons. This presentation will focus on the use of infrared multiphoton dissociation (IRMPD) and electron capture dissociation (ECD) for ion activation in quadrupole ion traps.

IRMPD has some advantages over CID in a quadrupole ion trap, and these advantages can be enhanced by the ion manipulation capabilities of the ion trap. A key difference between CID and IRMPD is that the former is mass-selective and a function of the ion trapping parameters. Occasionally the mass-selective nature of CID can be beneficial, but in general it is a limitation that is overcome with IRMPD. Several variations of the IRMPD experiment will be presented.

ECD is typically performed in FT-ICR instruments, but we have a unique ECD cell based on a linear ion trap that is part of a hybrid linear ion trap/time-of-flight (LIT/TOF) instrument. This instrument has the capability of performing CID and ECD on alternate scans on the LC time scale. Other experiments, which take advantage of the ion manipulation capabilities of the ion trap, involving ECD combined with other activation techniques, e.g. ECD+CID and ECD/IRMPD, will also be presented.

Speaker Background
Gary L. Glish received a B.A. from Wabash College in 1976 with majors in Chemistry and Economics. Deciding that he want to be able to do experiments to test hypotheses, he chose Chemistry over Economics for graduate school and obtained a Ph.D. from Purdue University (Advisor: R. Graham Cooks), in 1980. After receiving his Ph.D. Gary was a research scientist and group leader at Oak Ridge National Laboratory until 1992. In 1992 he took his current position on the faculty in the Department of Chemistry at the University of North Carolina.

Gary’s research interests are in the areas of mass spectrometry instrumentation, ion activation, ion chemistry, and development of methods for characterizing compounds of biological and environmental interest. In the area of instrumentation his focus has been on hybrid mass spectrometers and quadrupole ion traps. He has conceived and built several hybrid mass spectrometers including the first tandem quadrupole/time-of-flight mass spectrometer in 1984. He began his involvement with quadrupole ion traps in 1984 and more than half of his 100+ publications are related to quadrupole ion trap development and applications. His group was the first to couple ESI with a quadrupole ion trap. He is a co-author of a book on tandem mass spectrometry.

Gary is currently President of the American Society for Mass Spectrometry. He was VP for Programs for the 2007 and 2008 conferences and VP for Arrangements 1987-1989. He served as an associate editor for JASMS from 1989-2007. He was chair of the Lake Louise Workshop on Tandem Mass Spectrometry from 1999-2007.

Meeting details

Date:	Thursday	October 9,2008
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Presentation
Dinner:	featuring:	Salmon
		Chicken Florentine
		Grilled Vegetable Brochette
Cost:	$30	BAMS members*
	$40	Non-members
	$60	BAMS membership plus dinner cost
	$20	Students only
	$300	2008 Corporate Sponsors
		Dinner reservations required by noon on Tuesday, October 7, 2008

*Note:  BAMS memberships are for the calendar year and should be renewed with the first event you attend in 2008.  Dues ($30.00) may be paid while registering for dinner.  If you are unsure of your Membership status, please email Tim Hawkins.

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