ABSTRACT:

Determination of biological phenotype as a function of glycan expression is central to both fundamental cellular processes and applied biomarker development. The fact that glycans are biosynthesized as a distribution of glycoforms on a core structure vastly increases the complexity of the proteome and lipidome in a given biological context. Thus, glycosylation increases both the variability of expressed structures and the biological functions that result from interactions with binding partners. Key to the profiling of released glycan mixtures is a robust and sensitive liquid chromatography LC/MS interface. A chip-based interface will be described for amide-hydrophilic interaction chromatography-MS of released glycans and demonstrated for glycosaminoglycan oligosaccharides. The informatic treatment of glycomics LC/MS datasets differs significantly from that used in proteomics. Glycomics datasets resemble those used in metabolomics and lipidomics in that they comprise a series of structurally related metabolites. The assigning of biological meaning to the data is emerging as the most labor intensive in glycomics mass spectral workflows. A system for using a glycan structural database to query LC/MS datasets generated from heparan sulfate oligosaccharide mixtures will be described. The application of this approach to the comparative profiling of heparan sulfates from different organ tissues will be presented

SPEAKER BIOGRAPHY:

Joseph Zaia is an expert on applications of mass spectrometry in the field of glycomics. He has published on fundamental applied aspects of glycan analysis using tandem mass spectrometry and has developed an LC/MS platform for mass spectral glycomics. He has published a series of highly regarded reviews on this topic. Prof. Zaia received his Ph.D. in organic chemistry from MIT in 1993, working in the laboratory of Prof. Klaus Biemann on peptide sequencing by mass spectrometry. After a one-year post-doctoral fellowship at MIT, he did a second post-doc with Prof. Catherine Fenselau at the University of Maryland, focusing on mass spectrometry of metalloproteins. He joined the cartilage biochemistry group of Osiris Therapeutics, Inc., in June 1996 and worked on the characterization of glycoproteins and proteoglycans from connective tissue. In June 1999 he became Assistant Research Professor of Biochemistry at Boston University School of Medicine. Since this time he has served as Associate Director of the Mass Spectrometry Resource, a NIH/NCRR-funded research resource center. He was promoted to Associate Professor in 2009. He is author or co-author of 46 research publications.

This annual event does not include a regular focused scientific discussion, but it still will be an entertaining evening, offering an excellent opportunity to network with your colleagues and speak to representatives that sponsors our organization, and it has a finale with an exciting raffle of prizes donated by our favorite vendors and sponsors.


If you would like to become a sponsor and have not done so, please contact Tom Slyker or Maryann Shen. BAMS corporate sponsors for 2009 will have a place to put up a technical poster and a table to distribute literature or demonstrate products during Vendor Night.

SPEAKERS BIOGRAPHY: The Honorable and very much appreciated vendors and sponsors of BAMS.  
 
We look forward to seeing you there!
 
Respectfully, we remain your servants,

Your BAMS Executive Team.

Meeting details

Date:	Tuesday	November 17th, 2009
Time:	6:00 pm	Social hour, registration (no-host cocktails)
	7:00 pm	Dinner
	8:00 pm	Presentation
Dinner:	featuring:	Dinner selections are: A) Chicken Piccata- Sauteed with Lemon, Capers and White Wine.  B) Grilled Salmon- Champagne Brerre Blanc, Herb Roasted Veggies and Rice Pilaf. C) Penne Pasta Al Pomodoro- Roasted Vegetables topped with Tomatoes, Fresh Basil $ Pine Nuts(Vegetraian)
Cost:	$40	BAMS members*
	$50	Non-members
	$70	BAMS membership plus dinner cost
	$20	Students only
	$300	2009 Corporate Sponsors
		Dinner reservations required by 6:00 PM, Thursday the 12th of November, 2009

*Note:  BAMS memberships are for the calendar year and should be renewed with the first event you attend in 2009.  Dues ($30.00) may be paid while registering for dinner.  If you are unsure of your Membership status, please email Tom Slyker.

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1221 Chess Drive
Foster City, CA 94404 

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Hotel Phone: 1-800-972-3124